Last edited by Tuktilar
Thursday, July 16, 2020 | History

8 edition of Functional Protein Microarrays in Drug Discovery (Drug Discovery Series) found in the catalog.

Functional Protein Microarrays in Drug Discovery (Drug Discovery Series)

by Paul F. Predki

  • 60 Want to read
  • 39 Currently reading

Published by CRC .
Written in English

    Subjects:
  • Medical / Nursing,
  • Medical,
  • Pharmacy,
  • Biotechnology,
  • Pharmacology,
  • Medical / Pharmacy,
  • Chemistry - General,
  • Design,
  • Drugs,
  • Protein microarrays,
  • Proteins,
  • analysis

  • The Physical Object
    FormatHardcover
    Number of Pages480
    ID Numbers
    Open LibraryOL8261667M
    ISBN 100849398096
    ISBN 109780849398094

    Functional protein microarrays have recently been applied to many aspects of discovery-based biology, including protein–protein, protein–DNA, protein–RNA, protein–phospholipid, protein–drug, and protein–peptide interactions.   DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can Cited by:

      Meng L., Mattoon D., Predki P. () Small Molecule Protein Interaction Profiling with Functional Protein Microarrays. In: Roque A. (eds) Ligand-Macromolecular Interactions in Drug Discovery. Methods in Molecular Biology (Methods and Protocols), vol Humana Press, Totowa, NJ. First Online 03 October Cited by: 1. Protein microarrays have also been used in drug discovery for target identification and validation. In , Schreiber and co-workers described for the first time the use of a protein microarray for high-throughput screening of small molecules ().Cited by:

    Microarrays, an international, peer-reviewed Open Access journal. Dear Colleagues, The diversity of microarrays and their technological advantages have gained importance in the solving of different problems at the early stages of Drug Discovery and Development (DDD), ranging from high-throughput screening of compound libraries to preclinical assays.   (). An update on using protein microarrays in drug discovery. Expert Opinion on Drug Discovery: Vol. 2, No. 11, pp. Cited by: 4.


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Functional Protein Microarrays in Drug Discovery (Drug Discovery Series) by Paul F. Predki Download PDF EPUB FB2

Yet currently no book has addressed all aspects of functional microarrays in a coherent and integrated fashion. Until now. Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze array : Hardcover.

Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze array experiments.

As central actors in most biological functions, proteins are the subject of intense study. This has driven the development of increasingly sophisticated approaches for the study of proteins, which has extended to proteomic level methodologies.

Yet currently no book has addressed all aspects of functional microarrays in a coherent and integrated fasCited by:   Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze Functional Protein Microarrays in Drug Discovery book : Paul F.

Predki. Book Description: An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic principles, methods, and applications.

Download Citation | Functional protein microarrays in drug discovery | As central actors in most biological functions, proteins are the subject of intense study. This has driven the development of.

Functional protein microarrays promise new approaches to address longstanding challenges in drug discovery and development, with applications ranging from target identification to clinical trial design. However, their widespread adoption will be contingent upon a robust ability to develop and manufacture arrays in support of these by: From the reviews: “Microarray Methods for Drug Discovery is volume number of the Springer Protocols Methods in Biology Series.

it provides detailed experimental protocols for the use of microarrays in a variety of applications. chapters are obviously highly bespoke and would be of real value to laboratories wishing to establish the : Hardcover. This book is the first of its kind in the field of protein microarrays and addresses novel strategies for constructing highly functional and biocompatible microarrays for screening proteins.

The list of authors consisting of world leading experts provide a roadmap for solving the complex challenges that are currently faced while monitoring. Functional protein microarrays are emerging as a promising new tool for large-scale and high-throughput studies.

In this article, we will review their applications in basic proteomics research, where various types of assays have been developed to probe binding activities to other biomolecules, such as proteins, DNA, RNA, small molecules, and by: Yet currently no book has addressed all aspects of functional microarrays in a coherent and integrated fashion.

Until now. Meeting the need for comprehensive and authoritative information, Functional Protein Microarrays in Drug Discovery provides an up-to-date overview of the field and the background required to actually design and develop arrays or perform and analyze array cturer: CRC Press.

Functional protein microarrays in drug discovery Sapna K. Deo 1 Analytical and Bioanalytical Chemistry volumepages – () Cite this articleAuthor: Sapna K. Deo. The first reported use of functional protein microarrays for biological discovery purposes was reported by Snyder’s laboratory, which manufactured and used yeast proteome microarrays for protein interaction and lipid binding screens [1 •• ].

Since that time, a slowly increasing number of discovery-based papers have been by: Explores various aspects of functional protein microarrays, including basic principles, methods, and applications.

This book discusses the generation of functional protein content and describes fabrication methods. It presents a range of applications, from biomolecular interaction discovery and characterization to immune response profiling.

Protein microarray technology possesses some of the greatest potential for providing direct information on protein function and potential drug targets. For example, functional protein microarrays. An ideal text for biotechnologists, protein chemists, and biochemists, Functional Protein Microarrays in Drug Discovery explores all aspects of functional protein microarrays, including basic.

Buy Funct Pro Micro Drug Disc (Drug Discovery Series) 1 by Paul F. Predki (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders. detection types for assays on protein microarrays. This compre-hensive coverage does seem to meet the definition of the book’s title, Functional Protein Microarrays in Drug Discovery, but oth-erwise might be considered too encompassing.

Chapter 10 focuses on functional analysis of protein function at surfaces using surface plasmon resonance. Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science.

Author Bios Timothy D. Veenstra, PhD, is the Director of the Laboratory of Proteomics and Analytical Technologies, Department of Applied Science, Maranatha Baptist. From a scientific obscurity developed 15 years ago, microarrays have become a critical tool in pharmaceutical research and are providing a more in-depth analysis of the genome for improved drug discovery and development.

DRUG DISCOVERY AND DEVELOPMENT One of the first steps on the road to more efficient healthcare is developing better drugs to. Protein-Protein Interactions Small Molecule Interactions ATP ADP Enzymatic Assays 2.

Functional Protein Microarrays Two Major Types of Protein Microarrays •Protein Biochemical Activities •Protein Modification and Regulation •Protein Pathways •Drug Discovery and DevelopmentFile Size: 2MB. Here, we describe the field of functional genomics and review approaches that have been applied to drug discovery, including RNA profiling, proteomics, antisense and Cited by: Functional protein microarrays promise new approaches to address longstanding challenges in drug discovery and development, with applications ranging from target identification to clinical trial design.

However, their widespread adoption will be contingent upon a robust ability to develop and manufacture arrays in support of these applications.